Method for the manufacture of thip

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 498/04 (2006.01)

Patent

CA 2537840

The present invention relates to a new method of preparing gaboxadol (THIP), which is useful for treating sleep disorders. In particular a method of preparing THIP comprising reacting a compound of formula (8b) or a salt thereof with an acid, typically a mineral acid, to obtain THIP as an acid addition salt. The present invention also relates to several intermediates.

La présente invention concerne un nouveau procédé de préparation de gaboxadol (THIP) qui est utile pour traiter les troubles du sommeil. L'invention concerne notamment un procédé de préparation de THIP consistant à faire réagir un composé de la formule (8b) ou un sel de ce dernier avec un acide, généralement un acide minéral pour obtenir du THIP en tant que sel d'addition d'acide. La présente invention concerne également divers produits intermédiaires.

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