G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/53 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) C07K 16/18 (2006.01) C40B 40/10 (2006.01)
Patent
CA 2525781
Methods are provided for the prediction, diagnosis and differential diagnosis of Alzheimer's disease. More particularly, a method is provided to determine whether a subject that does not show any clinical signs of Alzheimer's disease has a likelihood to develop Alzheimer's disease. Further a method is provided for the diagnosis of subjects suffering from Alzheimer's disease and/or for the differential diagnosis of subjects suffering from Alzheimer's disease versus subjects suffering from other dementias such as dementia with Lewy bodies. The methods are based on the determination of the ratio of specific A.beta. peptides.
L'invention concerne des procédés de prédiction, diagnostic et diagnostic différentiel de la maladie d'Alzheimer. Plus particulièrement, l'invention concerne un procédé permettant de déterminer si un sujet ne présentant aucun signe clinique de la maladie d'Alzheimer est susceptible de développer la maladie. Par ailleurs, l'invention concerne un procédé de diagnostic appliqué à des sujets souffrant de la maladie d'Alzheimer et/ou un procédé de diagnostic différentiel appliqué à des sujets souffrant de la maladie d'Alzheimer et mettant en comparaison ces derniers avec des sujets souffrant d'autres troubles démentiels, tels que la démence à corps de Lewy. Ces procédés reposent sur la détermination du taux de peptides A.szlig. spécifiques.
Blennow Kaj
de Meyer Geert
Kostanjevecki Vesna
Vanderstichele Hugo
Vanmechelen Eugeen
Innogenetics N.v.
Smart & Biggar
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