C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/267.1, 260/2
C07D 241/04 (2006.01) C07D 243/08 (2006.01) C07D 295/04 (2006.01) C07D 295/088 (2006.01)
Patent
CA 1215979
ABSTRACT Compounds of formula I Image (wherein R is hydrogen or -?-NH-A: A is alkyl of 1 to 8 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, or unsubstituted or mono-, di- or tri-substituted phenyl, where the substituents are each alkyl of 1 to 4 carbon atoms, halogen, trihalomethyl, alkoxy of 1 to 4 carbon atoms, carboxylic acyl of 1 to 4 carbon atoms, carboxyl, (alkoxy of 1 to 3 carbon atoms)carbonyl, nitro, cyano or di(alkyl of 1 to 3 carbon atoms)amino; R1, R2 and R3, which may be identical to or different from each other, are each hydrogen, halogen, alkyl of 1 to 4 carbon atoms, trihalomethyl, nitro, cyano, di(alkyl of 1 to 4 carbon atoms)amino, (alkoxy of 1 to 4 carbon atoms)carbonyl, alkoxy of 1 to 4 carbon atoms or hydroxyl; R4 and R5, which may be identical to or different from each other, are each hydrogen, alkyl of 1 to 4 carbon atoms or phenyl; R6, R7, R8 and R9, which may be identical to or different from each other, are each hydrogen or methyl; Y is -CH2- or -CH2-CH2-; j is 0 or 1; k and m are each integers of 0 to 3, their sum being no more than 6 and being o when j is 1; and n is an integer of 2 to 4, with the proviso that n is 3 or 4 when R1 is hydrogen or 2 methyl, R2, R3, R4, R5, R6, R7, R8, R9 and R are hydrogen, j, k and m are 0, and Y is -CH2-) and acid addition salts thereof. The compounds as well as their physiologically acceptable salts are useful for the treatment of immunological, inflammatory and allergic disorders.
455423
Barsumian Edward L.
Devlin John P.
Hargrave Karl D.
Boehringer Ingelheim Limited
Fetherstonhaugh & Co.
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