Method for the preparation of 5,11-dihydro-6h-dipyrido...

Details Method for the preparation of 5,11-dihydro-6h-dipyrido... Method for the preparation of 5,11-dihydro-6h-dipyrido...

C - Chemistry, Metallurgy

07

D

C07D 471/14 (2006.01) C07D 213/73 (2006.01) C07D 213/82 (2006.01)

Patent

CA 2052946

ABSTRACT A method for preparing certain 5,11-dihydro-6H- dipyrido[3,2-b:2',3'-e][1,4]diazepines which comprises the following steps: 1. converting a 2,6-dichloro-3-pyridinecarboxamide to a 2,6-dichloro-3-aminopyridine by Hofmann Rearrangement; 2. reacting the 2,6-dichloro-3-aminopyridine with a 2- chloronicotonic acid to produce a 2,6-dichloro-3-(2'- chloro-3'-nicotinyl)carboxamidopyridine; 3. reacting the 2,6-dichloro-3-(2'-chloro-3'-nicotinyl) carboxamidopyridine with an amine to produce a 2,6- dichloro-3-(2'-amino-3'-nicotinyl)carboxamidopyridine; and 4. hydrogenating the 2,6-dichloro-3-(2'-amino-3'- nicotinyl)carboxamidopyridine to produce the 5,11- dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine.

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