Method for the preparation of a coated solid medicament

Details Method for the preparation of a coated solid medicament Method for the preparation of a coated solid medicament

A - Human Necessities

61

K

167/169

A61K 9/36 (2006.01) A61K 47/00 (2006.01)

Patent

CA 1308357

ABSTRACT OF THE DISCLOSURE Instead of using a uniform aqueous solution of a water-so- luble cellulose ether as a coating liquid of solid medicament forms, e.g., granules and tablets, to form a film-forming layer, an aqueous dispersion of a cellulose ether, which is soluble in cold water but insoluble in hot water, is used as a coating liquid at a temperature higher that the solubilization temperature, i.e. the critical point of the solubility behavior, followed by plasticization of the cellulose ether particles with water to cause fusion thereof. The coating liq- uid is freed from the limitation by the flowability even when the content of the cellulose ether is much higher than in the conven- tional solution-type coating liquid. In addition to the greatly de- creased time taken for forming a coating layer in a desired coating amount, moreover, cellulose ethers having a high degree of polymerization, which cannot be used in the conventional method, can be used so that the resultant film-coating layer is much strong- er than otherwise to provide a sustainedly releasing coating layer.

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