Method for the preparation of a controlled release system

Details Method for the preparation of a controlled release system Method for the preparation of a controlled release system

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 9/16 (2006.01) A61K 9/51 (2006.01) A61K 47/32 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2738707

Method for the preparation of a controlled release system Abstract The present invention relates to a method for the preparation of a controlled release system and especially to a method for entrapment of compounds in polymer carriers for controlled release of active ingredients, preferably bioactive ingredients, such as drugs. This method results in a system for controlled release of active ingredients and especially for controlled drug delivery. In accordance with the present invention, the term controlled release"encompasses all kinds of controlled release, including slow release, sustained and delayed release. Particularly, the present invention results in active ingredients, entrapped in or otherwise incorporated in or coupled to polymer carriers or polymeric devices, such as micelles, nanoparticles, microspheres and other types of polymer devices for controlled release; the active ingredients are covalently bonded to the polymer carriers or polymeric devices.

La présente invention concerne un procédé d'élaboration d'un système à libération contrôlée, et plus particulièrement un procédé de piégeage de composés dans des vecteurs polymères en vue d'une libération contrôlée des principes actifs, de préférence des agents biologiquement actifs, tels que des médicaments. Le procédé aboutit à un système permettant une libération contrôlée de principes actifs, et plus particulièrement une administration contrôlée des médicaments. Aux termes de la présente invention, l'expression "libération contrôlée" englobe toutes les sortes de libérations contrôlées, et notamment la libération lente, la libération prolongée et la libération retardée. En particulier, la présente invention permet l'obtention de principes actifs piégés, incorporés, ou couplés pour libération contrôlée à des vecteurs polymères ou à des dispositifs polymériques, tels que des micelles, des nanoparticules, des microsphères et d'autres types de dispositifs polymères. Les principes actifs sont liés par covalence aux vecteurs polymères ou aux dispositifs polymériques.

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