Method for the preparation of .alpha.-bromolactam derivatives

C - Chemistry – Metallurgy – 07 – D

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C07D 207/273 (2006.01) C07D 403/02 (2006.01) C07D 463/22 (2006.01) C07D 498/04 (2006.01) C07D 501/00 (2006.01) C07D 501/04 (2006.01) C07D 501/24 (2006.01) C07D 505/00 (2006.01)

Patent

CA 2231631

The invention is concerned with a new process for the preparation 1. Method for the manufacture of compounds of formula (see fig.I) wherein R is hydrogen, lower alkyl, lower alkoxy, cycloalkyl, cyclo-alkenyl, cycloalkyl-lower alkyl, lower alkenyl, lower alkynyl, aryl, aryl-lower alkyl, heterocyclyl or heterocyclyl-lower alkyl; the lower alkyl, cycloalkyl, lower alkenyl, cycloalkenyl, lower alkynyl, aryl-lower alkyl, aryl and the heterocyclyl moieties being unsubstituted or substituted with at least one group selected from carboxy, amino, carbamoyl, nitro, cyano, lower alkyl, lower alkoxy, hydroxy, halogen, and it is further concerned with the use of compounds prepared according to above mentioned process for the preparation of cephem, isocephem and carbacephem derivatives.

La présente invention concerne un nouveau procédé pour la préparation 1. Méthode pour la fabrication de composés de formule (voir fig. I) où R est un atome d'hydrogène ou un groupe alkyle inférieur, alcoxy inférieur, cycloalkyle, cyclo-alkényle, cycloalkyl-alkyle inférieur, alkényle inférieur, alkynyle inférieur, aryle, aryl-alkyle inférieur, hétérocyclyle ou hétérocyclyl-alkyle inférieur; les groupes alkyle inférieur, cycloalkyle, alkényle inférieur, cycloalkényle, alkynyle inférieur, aryl-alkyle inférieur, aryle et les parties hétérocyclyle étant non substitués ou substitués par au moins un groupe choisi parmi les groupes carboxy, amino, carbamoyle, nitro, cyano, alkyle inférieur, alcoxy inférieur, hydroxy ou des atomes d'halogène, et l'invention concerne également l'utilisation de composés préparés selon le procédé susmentionné pour la préparation de dérivés de céphème, d'isocéphème et de carbacéphème.

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