Method for the preparation of aminophosphine ligands and...

C - Chemistry – Metallurgy – 07 – F

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C07F 9/50 (2006.01) B01J 31/24 (2006.01) B01J 37/00 (2006.01) C07F 9/6568 (2006.01) C07F 9/6571 (2006.01)

Patent

CA 2689239

The present application is directed to i) a method for synthesizing aminophosphine (P,N) and phosphine-aminophosphine (P,N,P) ligands, ii) the use of such ligands in the preparation of metal complexes as hydrogenation catalysts, and iii) aminophosphine (P,N) and phosphine-aminophosphine (P,N,P) ligands of various structures. In particular, the methods in i) involve reacting a protected tertiary amine of formula (I) with a metal phosphide of the formula Y-PR8R9 to afford an aminophosphine of formula (II), which can then be optionally further reacted with a phosphine of the formula (III) to afford the phosphine-aminophosphine of formula (IV).

La présente invention concerne (i) un procédé en deux opérations de synthèse de ligands phoshine-aminophosphine (P,N,P), (i) l'utilisation de tels ligands pour l'obtention de complexes métalliques tels que des catalyseurs d'oxygénation, et (iii) des ligands aminophosphine (P,N) et phosphine-aminophosphine (P,N,P) de structures diverses. Plus particulièrement, ce procédé en deux opérations de (i) consiste à faire réagir une amine tertiaire protégée de formule (1) avec un phosphure de métal représenté par la formule Y-PR8R9 pour l'obtention d'une aminophosphine de formule (II), laquelle est ensuite mise en réaction avec un phosphine de formule (III) pour l'obtention d'une phosphine-aminophosphine de formule (IV).

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