Method for the preparation of an improved mutant strain of...

Details Method for the preparation of an improved mutant strain of... Method for the preparation of an improved mutant strain of...

C - Chemistry, Metallurgy

12

N

167/135, 195/49

C12N 15/00 (2006.01) A61K 39/02 (2006.01) A61K 39/10 (2006.01) C12N 1/20 (2006.01) C12N 15/01 (2006.01)

Patent

CA 1185549

Abstract of the Disclosure: The invention provides a method for the preparation of a new mutant strain of Bordetella bronchiseptica having a plurality of hereditary chromosomal markers comprising at least temperature-sensitivity and urease negativity. In particular, the invention provides a phase I mutant strain of B. bronchiseptica having excellent immunity and high safety, which is useful for the preparation of a live attenuated vaccine for prophylaxis of B. bronchiseptica infection, and also a live attenuated vaccine prepared there- from. The mutant strain is obtained by applying a mutagen to a strain of B. bronchiseptica to provide a mutant strain having temperature sensitivity and urease negativity, culturing the mutant strain, picking up a cell growth with a relatively small colony, and repeating the procedure of picking up a cell and culture thereof to convert it to a phase I organism having capsular antigen and which is hemolytic.

409089

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