Method for the preparation of antibody-fragment conjugates

Details Method for the preparation of antibody-fragment conjugates Method for the preparation of antibody-fragment conjugates

G - Physics

01

N

167/129, 167/139

G01N 33/535 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) G01N 33/532 (2006.01) G01N 33/68 (2006.01)

Patent

CA 1322341

ABSTRACT OF THE DISCLOSURE A novel method for preparing soluble antibody fragment compositions having superior characteristics for targeted delivery when administered in vivo are disclosed. The antibody fragment compositions are characterized by substantially the same immunospecificity as the unconjugated antibody and aqueous solubility such that they are suitable for in vivo adminstration. Therapeutic and diagnostic methods utilizing the antibody fragment compositions are also disclosed.

589927

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