Method for the preparation of .beta.-hydroxyketones

Details Method for the preparation of .beta.-hydroxyketones Method for the preparation of .beta.-hydroxyketones

C - Chemistry, Metallurgy

07

C

C07C 45/72 (2006.01) C07C 49/17 (2006.01) C07C 49/24 (2006.01) C07C 205/45 (2006.01) C07C 319/20 (2006.01) C07D 309/06 (2006.01) C07D 335/02 (2006.01) C07C 323/22 (2006.01)

Patent

CA 2044580

16 Abstract The present invention relates to in a method for the preparation of .beta.- hydroxydetones represented by general formula Image (where R is an alkyl group which may have a methyl group at the a position. an alkyl group substituted by alkylthio group which may have a methyl group at the a position, an alicyclic group which may have substituents at positions other thanthe .alpha., .beta. and .beta.' positions. a heterocyclic group which may have substituents at positions other than the .alpha.,.beta. and .beta.' positions. and phenyl group which may have an electron withdrawing group at the para position). by reacting aldehydes represented by the formula RCHO (A) (where R is as defined above) with aqueous solution of alkali metal salt of acetoacetic acid represented by the formula Image (B) (where M ? is an alkali metal ion), a method for the preparation of the said .beta.- hydroxyketones which comprises reacting (A) and (B) when a mole ratio of (A) to (B) is 1.0 to 1.5 if (A) has two a hydrogen atoms, 1.5 to 2.0 if one a hydrogen atom. 2. 0 to 2.5 if no a hydrogen atom and 1.1 to 1.5 if R is a phenyl group with electron withdrawing group at the para position even if no a hydrogen atom. at p? of 9 to 10.

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