Method for the preparation of citalopram

Details Method for the preparation of citalopram Method for the preparation of citalopram

C - Chemistry, Metallurgy

07

D

C07D 307/87 (2006.01) A61K 31/343 (2006.01) A61P 25/24 (2006.01) C07C 255/56 (2006.01) C07C 309/63 (2006.01)

Patent

CA 2291133

A method for the preparation of citalopram comprising reaction of a compound of Formula IV (see above formula) wherein R is C1-6 alkyl, acyl, C1-6 alkylsulfonyl or arylsulfonyl, with 3-(N,N- dimethylamino)-propyl magnesium halide, to prepare citalopram.

L'invention concerne un procédé de préparation de citaloprame consistant à faire réagir un composé avec de l'halogénure de 3-(N,N-diméthylamino)-propyle magnésium. Ce composé est représenté par la formule (IV), dans laquelle R représente alkyle C1-6, acyle, arylsulfonyle ou alkylsufonyle C1-6.

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