C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/87 (2006.01)
Patent
CA 2383963
A method for the manufacture of citalopram characterised in(i) reaction of 1- (4ï-fluorophenyl)-1-(3-dimethylaminopropyl)-5-halophtalane with activated magnesium to form the Grignard reagent [3-[1-(4-fluorophenyl)-1,3 dihydro- isobenzofuran-1-yl]propyl]dimethylamine 5-magnesium halide followed by (ii) reaction of [3-[1-(4-fluorophenyl)-1,3 dihydro-isobenzofuran-1- yl]propyl]dimethylamine 5-magnesium halide with a compound containing a -CN group bound to a leaving group to form citalopram.
L'invention concerne un procédé de fabrication de citaloprame caractérisé en ce qu'il consiste (i) à faire réagir un 1-(4ï-fluorophényl)-1-(3-diméthylaminopropyl)-5-halophtalane avec du magnésium activé pour former le réactif de Grignard halogénure de [3-[1-(4-fluorophényl)-1,3 dihydro-isobenzofuran-1-yl]propyl]diméthylamine 5-magnésium, puis (ii) à faire réagir un halogénure de [3-[1-(4-fluorophényl)-1,3 dihydro-isobenzofuran-1-yl]propyl]diméthylamine 5-magnésium avec un composé dont un groupe -CN est lié à un groupe partant de manière à former du citaloprame.
Bolzonella Eva
Castellin Andrea
Bolzonella Eva
Castellin Andrea
H. Lundbeck A/s
Nicole' Andrea
Robic
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