A - Human Necessities – 61 – F
Patent
A - Human Necessities
61
F
A61F 2/02 (2006.01) A61K 9/50 (2006.01) A61K 47/30 (2006.01)
Patent
CA 2532302
The methods disclosed herein are of use for the production of controlled release compositions. In particular, the methods provide the contacting of an organic phase containing a bioactive agent and a polymer with an aqueous phase containing an organic ion to create controlled release compositions containing bioactive agents. The present invention also includes controlled release compositions including a polymer, an organic ion and a bioactive agent. The present invention also includes methods of using such controlled release compositions. The usefulness of the present invention is that the methods result in the production of controlled release compositions containing bioactive agent capable of administration in a concentrated low-dose form, having low burst and reduced production of degraded bioactive agent.
L'invention concerne des procédés de production de compositions à libération régulée. Lesdits procédés consistent en particulier à mettre en contact une phase organique contenant un agent bioactif et un polymère avec une phase aqueuse contenant un ion organique, de sorte à produire des compositions à libération contrôlée contenant des agents bioactifs. L'invention concerne également des compositions à libération contrôlée contenant un polymère, un ion organique et un agent bioactif. L'invention concerne encore des procédés d'utilisation de ces compositions. La présente invention permet donc de produire des compositions à libération contrôlée contenant un agent bioactif permettant une administration sous forme de faible dose concentrée, présentant un éclatement faible et une production réduite d'agent bioactif dégradé.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Pr Pharmaceuticals Inc.
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