C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/74 (2006.01) A61K 31/44 (2006.01) A61P 3/06 (2006.01) A61P 7/12 (2006.01)
Patent
CA 2575283
A method for the preparation of crystal form 1 of polymorphous crystalline torsemide, wherein torsemide is dissolved in an ethanol-water mixture with heating, after which the torsemide is subsequently cooled and dried once crystal separation has been performed. Drying takes place in a blade drier, for example, with the crystals being subjected to mechanical stress, wherein the crystals of crystalline form 2 are transformed into crystalline form 1.
L'invention concerne un procédé pour isoler la forme cristalline 1 de la torasémide cristalline polymorphe. Ce procédé consiste : à dissoudre la torasémide dans un mélange éthanol-eau, ce qui génère de la chaleur, puis ; à refroidir la solution et à la sécher après la séparation des cristaux. Cette invention est caractérisée en ce que le séchage est effectué dans un séchoir à aubes, par exemple, tandis que les cristaux sont soumis à des contraintes mécaniques, les cristaux de la forme cristalline 2 étant transformés en cristaux de la forme cristalline 1.
Gerdenitsch Anton
Kuehnhackl Peter
Welzig Stefan
Borden Ladner Gervais Llp
Sanochemia Pharmazeutika Ag
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