Method for the preparation of directly compressible granular...

Details Method for the preparation of directly compressible granular... Method for the preparation of directly compressible granular...

C - Chemistry, Metallurgy

07

C

260/641, 260/632

C07C 29/76 (2006.01) A61K 9/20 (2006.01) B01J 2/20 (2006.01) C07C 31/26 (2006.01)

Patent

CA 1272216

Method for the preparation of directly compressible granular mannitol A B S T R A C T The invention relates to a method of preparing directly compressible granular mannitol, characterized by the fact that a raw material essentially constituted of powder mannitol is subjected to an extrusion treatment inside an installation comprising a heating zone and an extrusion die, the supply flow rate of the installation with raw material as well as the parameters of the extru- sion treatment, namely the temperature existing inside the heating zone, the diameter of the extrusion die and the driving speed of the raw material inside the heating zone being selected so that at the exit of the die and before the exit of the mannitol from the latter. said mannitol is partly fused.

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