Method for the preparation of erythro vicinal amino-alcohols

Details Method for the preparation of erythro vicinal amino-alcohols Method for the preparation of erythro vicinal amino-alcohols

C - Chemistry, Metallurgy

07

F

C07F 7/10 (2006.01) A01N 43/54 (2006.01) A01N 43/66 (2006.01) A01N 57/24 (2006.01) C07C 213/00 (2006.01) C07C 213/08 (2006.01) C07C 215/30 (2006.01) C07C 323/45 (2006.01) C07D 307/20 (2006.01) C07D 307/33 (2006.01) C07D 309/12 (2006.01) C07D 309/30 (2006.01)

Patent

CA 2058111

DIR 0480 Abstract The present invention is concerned with the preparation of erythro N-substituted vicinal aminoalcohol derivatives from hydroxyl-protected cyanohydrin derivatives by successive Grignard reaction, transimination using a primary amine, reduction of the resulting imine and removal of the hy- droxyl-protecting group. The products are obtained either as a racemate or in an optically pure form, depending upon the stereochemical composition of the cyanohydrin derivatives.

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