Method for the preparation of escitalopram

Details Method for the preparation of escitalopram Method for the preparation of escitalopram

C - Chemistry, Metallurgy

07

D

C07D 307/87 (2006.01) C07B 57/00 (2006.01) C07C 215/32 (2006.01)

Patent

CA 2451124

A novel method is provided for the manufacture of escitalopram. The method comprises chromatographic separation of the enantiomers of citalopram or an intermediate in the production of citalopram using a chiral stationary phase such as ChiralpakTM AD or ChiralcelTM OD. Novel chiral intermediates for the synthesis of Escitalopram made by said method are also provided.

L'invention concerne un nouveau procédé de fabrication d'escitalopram. Ce procédé comporte une séparation chromatographique des énantiomères de citalopram ou d'un produit intermédiaire utile dans la production de citalopram, à l'aide d'une phase stationnaire chirale telle que Chiralpak?TM¿ AD ou Chiralcel?TM¿ OD. L'invention concerne aussi de nouveaux produits intermédiaires chiraux utiles dans la synthèse d'Escitalopram fabriqué selon le procédé.

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