Method for the preparation of glycopeptidic antibiotic...

Details Method for the preparation of glycopeptidic antibiotic... Method for the preparation of glycopeptidic antibiotic...

C - Chemistry, Metallurgy

07

K

C07K 9/00 (2006.01) C07K 5/087 (2006.01) C07K 7/06 (2006.01)

Patent

CA 2183333

Novel method for intermolecular cyclization by formation of a biaryl ether bridge through the reaction as shown above. In formulas (I) and (II) R¿1? is a nitro radical adjacent to the oxygen bridge, Hal is a fluoride or chlorine atom, R¿2?, R¿3? and R¿4? together form a peptidic chain, in the presence of a weak phase in a heterogeneous medium. The invention also concerns compounds of formulas (I) and (II) and the use of compounds of formula (I) to obtain useful compounds.

L'invention concerne un nouveau procédé de cyclisation intermoléculaire par formation d'un pont éther biaryl selon la réaction ci- dessus. Dans les formules (I) et (II) R1 est un radical nitro adjacent au pont oxygène, Hal est un atome de fluor ou de chlore, R2, R3, R4 ensemble forment une chaîne peptidique, en présence d'une base faible en milieu hétérogène. L'invention concerne également les composés de formules (I) et (II) et l'utilisation des composés de formule (I) pour obtenir des composés d'intérêt.

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