Method for the preparation of metoprolol

Details Method for the preparation of metoprolol Method for the preparation of metoprolol

C - Chemistry, Metallurgy

07

D

260/604.2

C07D 327/10 (2006.01) A61K 31/13 (2006.01) B01J 27/10 (2006.01) B01J 31/02 (2006.01) C07D 317/28 (2006.01)

Patent

CA 1198125

Abstract A process for the preparation of metoprolol or 1- isopropylamino-3-(4-(2-methoxy)ethylphenoxy)-2-propanol wherein 3-(4-(2-methoxy)ethyl)phenoxy-1,2-propanediol is reacted with thionyl chloride in dichlormethane in the presence of triethylamine to form 4-(4-((2-methoxy- ethyl)phenoxy)methyl)-1,3,2-dioxathiolane-2-oxide Image which is then reacted with isopropylamine in acetonitrile.

417934

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