Method for the preparation of montelukast acid in ionic...

Details Method for the preparation of montelukast acid in ionic... Method for the preparation of montelukast acid in ionic...

C - Chemistry, Metallurgy

07

D

C07D 215/18 (2006.01)

Patent

CA 2701912

The present invention relates to a method for preparing Montelukast acid or its sodium salt by reacting a thiol compound with a Montelukast intermediate in the presence of a base in a medium comprising an ionic liquid compound. In accordance with the inventive method, highly pure Montelukast acid or its sodium salt, which is advantageously used as a raw material in the preparation of Montelukast, a leukotriene antagonist, can be easily prepared in a high yield.

Procédé de fabrication d'acide montélukast ou de son sel acide, consistant à faire réagir un composé thiol avec un intermédiaire de montélukast en présence d'une base dans un milieu renfermant un composé liquide ionique. Le procédé de l'invention, permet d'obtenir facilement et à fort rendement un acide de montélukast d'une grande pureté ou son sel de sodium, qui convient avantageusement comme matière première pour la préparation du montélukast, un antagoniste du leucotriène.

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