C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 489/00 (2006.01) A61K 31/485 (2006.01) A61P 29/00 (2006.01) C07B 63/02 (2006.01) C07D 489/08 (2006.01)
Patent
CA 2705251
The present invention relates to a method for the preparation of morphine compounds comprising a low content of a,ß-unsaturated compounds, which comprises the steps of: (i) bringing the crude morphine compound into contact with a base, at a pH of greater than 13, under conditions which make possible the Michael addition reaction on the a,ß-unsaturated compound(s) present; (ii) separating the morphine compound from the reaction mixture; and (iii) if appropriate, separating the addition product formed, from the morphine compound. It also relates to a composition comprising at least 99% by dry weight of morphine compound, or of a pharmaceutically acceptable salt thereof, and an a,ß-unsaturated compound in a content of less than 100 ppm.
La présente invention concerne un procédé de préparation de composés morphiniques à faible teneur en composés .alpha.-.beta. insaturés, comportant les étapes de: (i) mise en contact du composé morphinique brut avec une base, à pH supérieur à 13 et dans des conditions permettant la réaction d'addition de Michael sur le(s) composé(s) .alpha.-.beta. insaturés présents; (ii) séparation du composé morphinique du mélange réactionnel; et (iii) le cas échéant, séparation du produit d'addition formé du composé morphinique. Elle vise également une composition comprenant au moins 99 % en poids sec de composé morphinique ou d'un de ses sels pharmaceutiquement acceptables et un composé .alpha.-.beta.-insaturé en une teneur inférieure à 100 ppm.
Robic
Sanofi-Aventis
LandOfFree
Method for the preparation of morphine compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for the preparation of morphine compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for the preparation of morphine compounds will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2007254