Method for the preparation of steroid derivative ketal

Details Method for the preparation of steroid derivative ketal Method for the preparation of steroid derivative ketal

C - Chemistry, Metallurgy

07

J

C07J 21/00 (2006.01) C07J 41/00 (2006.01) C07J 75/00 (2006.01)

Patent

CA 2191397

The invention relates to a method of the preparation of a steroid derivative ketal according to the general formula I: (see figure I) wherein R; is CH3 or C~H5; R2 is OH; R3 is H, CH3; C.ident.CH, CH2Hal,, or CH2CN; or R2 and R3 together are O; R4 is (2-5C) alkylene; and Hal is Cl, Br or I, characterized in that the compound of formula II: (see figure II) wherein R1, R2 and R3 have the previously given meanings, is treated in the presence of an orthoester of formula III: (see figure III) or an orthoester of formula IV: (see figure IV) wherein R4 has the previously indicated meaningor a mixture thereof with an alcohol according to the general formula HOR4OH, wherein R4 has the previously given meaning.

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