Method for the preparation of tetrahydrofolates

Details Method for the preparation of tetrahydrofolates Method for the preparation of tetrahydrofolates

C - Chemistry, Metallurgy

07

D

260/242.13

C07D 475/04 (2006.01) C07D 487/14 (2006.01)

Patent

CA 1339675

For the preparation of 5,10-methenyl-(6R)-, 5-formyl-(6S)- or 5-methyl-(6S)-tetrahydrofolic acid or salts thereof, 5,10-methenyl-(6R,S)-tetrahydrofolic acid, the inner salt thereof or one of the salts thereof with strong acids is subjected to diastereomer separation by fractional crystallization and, if desired, the resulting 5,10-methenyl-(6R)-tetrahydrofolic acid is converted by treatment with a hydrolyzing agent into 5-formyl-(6S)-tetrahydrofolic acid or by treatment with a reducing agent into 5-methyl-(6S)-tetrahydrofolic acid, and the resulting free acid may be converted into one of its salts by treatment with a base.

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