A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/21 (2006.01) A61K 31/19 (2006.01) A61K 31/35 (2006.01) A61K 38/17 (2006.01)
Patent
CA 2392568
The instant invention provides a method for raising serum HDL cholesterol levels comprising administering a therapeutically effective amount of an LXR ligand to a patient in need of such treatment. It further provides a method for using an LXR ligand to stimulate expression of the ABC1 gene. LXR ligands can be used for preventing and treating atherosclerosis and related conditions.
L'invention concerne un procédé d'élévation des taux sériques de cholestérol HDL, consistant à administrer une dose efficace sur le plan thérapeutique d'un ligand LXR à un patient nécessitant un tel traitement. L'invention concerne en outre un procédé d'utilisation d'un ligand LXR aux fins de stimulation de l'expression du gène ABC1. On peut utiliser des ligands LXR pour prévenir et traiter l'athérosclérose et des états associés.
Ondeyka John G.
Singh Sheo Bux
Sparrow Carl P.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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