C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/34 (2006.01)
Patent
CA 2513951
Disclosed is a method for producing d-threo-[R(R*,R*)]-2-phenyl-2-piperidine-2- yl acetate and the acid addition salts thereof by converting d-threo- [R(R*,R*)]-2-phenyl-2-piperidine-2-yl ethanoic acid or an acid addition salt thereof into the corresponding d-threo-[R(R*,R*)]-2-phenyl-2-piperidine-2-yl ethanoic acid halide, producing the desired d-threo-[R(R*,R*)]-2-phenyl-2- piperidine-2-yl acetate or an acid addition salt thereof by means of esterification, and optionally recrystallizing the obtained product. The invention also relates to methods for producing pure threo-2-phenyl-2- piperidine-2-yl acetamide or the starting material for producing d-threo- [R(R*,R*)]-2-phenyl-2-piperidine-2-yl ethanoic acid.
L'invention concerne un procédé de fabrication d'esters d'acide d-thréo-[R(R*,R*)]-2-phényl-2-pipéridine-2-yl-acétique, et de ses sels d'addition acide. Ledit procédé consiste à transformer l'acide d-thréo-[R(R*,R*)]-2-phényl-2-pipéridine-2-yl-acétique ou un de ses sels d'addition acide en halogénure d'acide d-thréo-[R(R*,R*)]-2-phényl-2-pipéridine-2-yl-acétique correspondant, à produire l'ester à partir de l'acide d-thréo-[R(R*,R*)]-2-phényl-2-pipéridine-2-yl-acétique ou d'un de sels d'addition acide par estérification, et à recristalliser éventuellement le produit obtenu. L'invention concerne également un procédé de fabrication d'amide d'acide thréo-2-phényl-2-pipéridine-2-yl-acétique pur, ou du produit de départ de la fabrication de l'acide d-thréo-[R(R*,R*)]-2-phényl-2-pipéridine-2-yl-acétique.
Trafelet Huldreich
Wollenweber Markus
Siegfried Ltd.
Smart & Biggar
LandOfFree
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