Method for the production of 2,3-cis-substituted 2-aryl...

C - Chemistry – Metallurgy – 07 – C

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C07C 45/74 (2006.01) C07C 47/232 (2006.01)

Patent

CA 2548916

The invention relates to a method for producing 2,3-cis-substituted 2-aryl propenals by condensing a 2-aryl acetaldehyde I with a non-enolizable aldehyde compound II in the presence of a base. The inventive method is characterized in that the reaction is carried out in a solvent mixture comprising at least one water-miscible organic solvent and water at a volume ratio Vsolvent: Vwater ranging between 10:1 and 0.5:1.

L'invention concerne un procédé pour la production de 2-arylpropénals 2,3-cis-substitués par condensation d'un 2-arylacétaldehyde (I) avec un composé aldéhyde (II) non énolisable, en présence d'une base. Ce procédé est caractérisé en ce que l'on effectue la réaction dans un mélange de solvant qui contient au moins un solvant organique miscible à l'eau et de l'eau dans un rapport volumique V¿ solvant?: V¿ eau? compris entre 10:1 et 0,5:1.

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