Method for the production of 2'-deoxyadenosine compounds

Details Method for the production of 2'-deoxyadenosine compounds Method for the production of 2'-deoxyadenosine compounds

C - Chemistry, Metallurgy

07

H

260/229.5

C07H 19/173 (2006.01) C07H 19/16 (2006.01)

Patent

CA 1269659

Abstract A method that is direct and stereospecific is provided for the production of 2'-deoxyadenosine derivatives and related analogs. The method comprises glycosylation of the sodium salt of 2,6-dichloropurine or 6-chloropurine and ammonolysis of the glycosylate to obtain the corresponding 2-chloro-2'-deoxyadenosine or 2'-deoxyadenosine. The method is useful for the production of the 2'deoxyadenosine compounds which in turn are useful cytotoxic agents.

486828

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