Method for the production of 6-hydroxynicotinic acid

Details Method for the production of 6-hydroxynicotinic acid Method for the production of 6-hydroxynicotinic acid

C - Chemistry, Metallurgy

12

P

195/131

C12P 17/12 (2006.01)

Patent

CA 1239362

METHOD FOR THE PRODUCTION OF 6-HYDROXYNICOTINIC ACID ABSTRACT OF THE INVENTION A process is disclosed for the production of 6-hydroxynicotinic acid by biotechnological methods. Nicotinic acid is enzymatically hydroxylated in the presence of an equivalent quantity of magnesium or barium ions with the help of a nicotinic acid-hydroxylating microorganism. The resultant magnesium or barium salt of the 6-hydroxy- nicotinic acid is separated from the reaction mixture. Then the 6-hydroxynicotinic acid is freed from the separated salts. Examples of the microorganism are those of the genus Pseudomonas, Bacillus or Achromobacter, for example, Achromobacter xylosoxydans. Preferably the enzymatic hydroxylation is carried out at 20° to 40°C. and a pH of 5.5 to 9.0 under aerobic conditions.

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