C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/63 (2006.01) A61K 48/00 (2006.01) C12N 15/10 (2006.01)
Patent
CA 2541240
The invention relates to a method for the production of a cell and/or tissue and/or disease phase specific medicament against chronic inflammatory diseases. Disease, cell-type, tissue and/or stage specific proteins and nucleic acids are identified with regard to the modified expression pattern and the corresponding nucleic acids are analyzed as possible attack targets for DNAzymes or siRNA. What follows is a design of active specific DNAzymes and siRNA which bind to the target sequence and cleave it such that a medicament against chronic inflammatory diseases and auto-immune diseases is provided.
L'invention concerne un procédé servant à produire un médicament spécifique de cellules et/ou de tissus et/ou de phases de maladies et convenant au traitement de maladies inflammatoires chroniques. A cet effet, des protéines et des acides nucléiques spécifiques de la maladie, du type de cellule, du tissu et/ou du stade de la maladie sont identifiés quant à leur profil d'expression modifié et les acides nucléiques correspondants sont analysés en tant que cibles d'attaque possibles pour des ADNzymes ou des ARNsi. On conçoit ensuite des ADNzymes et des ARNsi spécifiques actifs qui se lient à la séquence cible et qui la clivent de sorte qu'on dispose d'un médicament contre des maladies inflammatoires chroniques et contre des maladies auto-immunes.
Renz Harald
Sel Serdar
Marks & Clerk
Philipps-Universitaet Marburg
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