Method for the production of a solvent-free .alpha.-lipoic acid

C - Chemistry – Metallurgy – 07 – D

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C07D 339/04 (2006.01)

Patent

CA 2380495

Solvent-free .alpha.-lipoic acid is produced by dissolving a) the .alpha.-lipoic acid to be purified in aqueous alkaline solution, or dissolving the salt thereof in water and adjusting an alkaline pH, b) removing solid impurities present where appropriate from the aqueous solution from stage a), c) adjusting the aqueous solution from stage a) or b) to a pH of from 1.0 to 5.0 with the aid of an acid and d) isolating the precipitated .alpha.-lipoic acid by known methods. This results in a solvent-free .alpha.-lipoic acid with improved chemical purity.

La présente invention concerne la préparation d'acide alpha -lipoïque dépourvu de solvant, par les étapes suivantes: a) dilution de l'acide alpha -lipoïque à purifier dans une solution alcaline aqueuse ou de l'un de ses sels dans l'eau et réglage du pH à une valeur alcaline; b) éventuellement séparation des impuretés solides présentes dans la solution aqueuse de l'étape a); c) réglage du pH de la solution aqueuse de l'étape a) ou b) à une valeur comprise entre 1,0 et 5,0 au moyen d'un acide; et d) isolation de l'acide alpha -lipoïque obtenu, grâce à des procédés connus. Cette méthode permet d'obtenir de l'acide alpha -lipoïque dépourvu de solvant, ayant une pureté chimique améliorée.

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