C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/0781 (2010.01) C12N 5/078 (2010.01) C07K 16/00 (2006.01) C12N 5/16 (2006.01) C12N 15/00 (2006.01) C12N 15/08 (2006.01) C12P 21/08 (2006.01) C12Q 1/00 (2006.01)
Patent
CA 2650109
The current invention is related to a method for the production of a human monoclonal antibody from an immundeficient non-human animal, said method comprising contacting a newborn immunodeficient non-human animal with a human fetal liver stem cell (FL cell) to generate an immune transplanted non- human animal (reconstituted animal), subsequently contacting said reconstituted animal with an antigen, collecting from said reconstituted animal a human cell producing human antibody against said antigen, and isolating said antibody from said antibody producing cell.
La présente invention concerne un procédé destiné à la production d'un anticorps monoclonal humain à partir d'un animal non humain immunodéficient, ledit procédé consistant à mettre en contact un animal nouveau-né non humain immunodéficient avec une cellule souche hépatique fAEtale humaine (cellule HF) afin de générer un animal non humain transplanté et immun (animal reconstitué), puis à mettre en contact ledit animal reconstitué avec un antigène, à prélever dudit animal reconstitué une cellule humaine produisant un anticorps humain contre ledit antigène, et à isoler ledit anticorps de ladite cellule productrice de l'anticorps.
Lifke Alexander
Lifke Valeria
Mueller-Beckmann Bernd
Schnitzer Tobias
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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