Method for the production of bead dextran materials for gel...

C - Chemistry – Metallurgy – 08 – B

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C08B 37/02 (2006.01) B01J 20/22 (2006.01) B01J 20/291 (2006.01)

Patent

CA 1263379

ABSTRACT OF THE DISCLOSURE: A method for the production of bead dextran materials for gel chromatography, wherein dextran is, be- fore or during the suspension process or in both stages, subjected to reduction in an alkaline solution, advanta- geously by the action of sodium borohydride. The density of crosslinking is controlled above all by variation of the concentration of the initial dextran solution and the re- sulting gel is optionally subjected to the additional crosslinking in a separate subsequent operation. The pro- cedure according to the invention provides the product of higher quality with a lower content of carboxylic groups and substantially facilitates the preparation of gels with a very high and a very low crosslink density.

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