C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 19/00 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) C12N 15/67 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2215362
A method for the microbial production of a cationic peptide having anti- microbial activity is provided, wherein the cationic peptide is first produced as a fusion protein having an anionic portion for suppressing the anti- microbial activity of the cationic portion. A novel cationic peptide having anti-microbial activity and LPS-binding activity is also provided. Such peptides are useful for suppressing the growth of bacteria and for the treatment of endotoxemia-associated disorders.
On décrit un procédé de production microbienne d'un peptide cationique possédant une activité antimicrobienne, lequel peptide est d'abord produit en tant que protéine de fusion présentant une portion anionique aux fins de suppression de l'activité antimicrobienne de la portion cationique. On décrit également un nouveau peptide cationique possédant une activité antimicrobienne ainsi qu'une activité de liaison aux lipopolysaccharides. De tels peptides sont utiles pour supprimer la prolifération des bactéries et pour traiter les troubles associés à l'endotoxémie.
Brown Melissa H.
Hancock Robert E.w.
Kelly Niamh
Piers Kevin L.
Mbm & Co.
University Of British Columbia
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