A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/135, 195/128
A61K 39/10 (2006.01) C07K 14/235 (2006.01) A61K 39/00 (2006.01)
Patent
CA 1213234
- 33 - Abstract of the Disclosure: METHOD FOR THE PRODUCTION OF HA FRACTION CONTAINING PROTECTIVE ANTIGENS OF BORDETELLA PERTUSSIS AND PERTUSSIS VACCINE A method for production of HA fraction containing protective antigens of Bordetella pertussis (i.e. a fraction containing F-HA and LPF-HA) in an industrial scale, for instance, with a fermentater, which comprises inoculating a strain of B. pertussis in a liquid culture containing a cyclodextrin or its derivative, culturing it by a spinner culture under controlling the culture temperature and the amount of dissolved oxygen and under defoaming condition, optionally under controlling the pH range, and harvesting the produced HA fraction from the culture broth at a stage of from logarithmic growth phase to static grow phase, and a method for production of a pertussis vaccine from the HA fraction thus obtained by formalinizing the HA fraction in the presence of an amino acid.
450495
Ginnaga Akihiro
Kitagawa Hisashi
Koba Hiroshi
Sakuma Shin
Suzuki Yoji
Juridical Foundation The Chemo-Sero-Therapeutic
Kirby Eades Gale Baker
Teijin Limited
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