Method for the production of human monoclonal antibodies

Details Method for the production of human monoclonal antibodies Method for the production of human monoclonal antibodies

C - Chemistry, Metallurgy

12

N

167/37, 195/1.10

C12N 5/24 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) C12N 15/10 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2033984

2033984 9100342 PCTABS00003 The process of the invention comprises the following steps: (a) isolation and preparation of cells exhibiting antigens, TH and B cell precursors from tumour-infiltrated people, those infected with procaryotic or eucaryotic exciters, especially viruses, or those with a hereditary disease; (b) activation of the TH and B cell precursors of (a) by bonding to the cells of (a) exhibiting antigens; (c) isolation and preparation of B cells from tumour-infiltrated people, those infected with procaryotic or eucaryotic exciters, especially viruses, those with a serious disease or healthy people; (d) activating the B cells of (c) by bonding to the antigen-activated TH and B cell precursors of (b), and (e) cloning the activated B cells of (d).

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