C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/02 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2415464
The present invention relates to a method for the production of collagen-like compounds containing hydroxylated proline residues. Of specific interest is the production of recombinant collagen-like compounds in which hydroxylation of proline residues is achieved by a prolyl hydroxylase from a fungus, preferably a yeast, in particular Hansenula polymorpha. Also the invention concerns a method for controlling the hydroxylation of proline residues by such a prolyl hydroxylase characterised by the addition of collagen-like oligopeptides, such as gelatine hydrolysate, in particular gelatone or peptone.
Cette invention a trait à un procédé de production de composés du type collagène contenant des restes proline hydroxylés. Elle concerne, notamment, la production de composés du type collagène de recombinaison dans lesquels l'hydroxylation du reste proline est réalisée à l'aide d'une prolyl hydroxylase issue d'un champignon, une levure, de préférence, en particulier Hansenula polymorpha. L'invention porte, en outre, sur une technique permettant de commander l'hydroxylation des restes proline au moyen de cette prolyl hydroxylase, laquelle technique se caractérise par l'ajout d'oligopeptides du type collagène, comme un hydrolysat de gélatine, en particulier la gélatone ou la peptone.
de Bruin Eric Christiaan
de Wolf Frederik Anton
Werten Marc Willem Theodoor
Ato B.v.
Mccarthy Tetrault Llp
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