A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/139
A61K 39/395 (2006.01) C07K 16/06 (2006.01)
Patent
CA 1137413
METHOD FOR THE PRODUCTION OF IMMUNOGLOBULIN HAVING A HIGH MONOMER CONTENT Abstract of the Disclosure: The specification relates to a method for the production of immunoglobulin having a high monomer content from immunoglobulin-containing materials by a fractionation method. The method comprises carrying out the fractionation in the presence of a water-soluble, basic nitrogen-containing organic compound having a dissociation constant (pKb) of 7 or less, or an acid addition salt thereof, and thereby inhib- iting the by-production of undesirable aggregated molecules. The immunoglobulin has a high monomer content and contains little or no aggregated molecules and hence can be used as a medicine in immune prophylaxis and immunotherapy without undesirable side effects and can be administered by an intravenous route, and further, is useful for the preparation of chemically treated immunoglobulins having a high monomer content.
358470
Funatsu Akinobu
Ohashi Komei
Ono Shoji
Sato Tetsuro
Yoshida Tsunemasa
Juridical Foundation The Chemo-Sero-Therapeutic
Kirby Eades Gale Baker
Teijin Limited
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