C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 17/08 (2006.01)
Patent
CA 2598139
A process for the conversion of 6-11 bridged bicyclic ketolide or erythromycin oximes to 6-11 bridged bicyclic ketolides or erythromycins comprises reacting a 6-11 bridged macrolide with a deoximating agent, preferably an oxidative deoximating agent such as Dess-Martin periodinane. The procedure may comprise deoximation of certain erythromycin A C-9 oxime derivatives with regeneration of the C-9 keto function.
L'invention porte sur un procédé de conversion d'un cétolide bicyclique ou d'oximes d'érythromycine à pontage 6-11 en cétolides bicycliques ou érythromycines à pontage en 6-11, consistant à faire réagir un macrolide à pontage en 6-11 avec un agent de déoxymation, de préférence un agent de déoxymation oxydant tel que du Dess-Martin periodinane. Ce procédé comprend la déoxymation de certains dérivés d'érythromycine A C-9 oxime accompagnée de la régénération de la fonction C-9 céto.
Alpharma Aps
Deeth Williams Wall Llp
LandOfFree
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