Method for the production of magnesium...

C - Chemistry – Metallurgy – 07 – F

Patent

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C07F 9/58 (2006.01) C07D 213/66 (2006.01)

Patent

CA 2230555

The invention relates to a method for the production of magnesium pyridoxal-5'- phosphate glutamate, in which pyridoxine or an acid addition salt thereof is oxidised with manganese (IV) oxide to pyridoxal; pyridoxal is reacted with p- phenetidine under formation of the Schiff's base p-phenetidyl-pyridoxal; p- phenedityl-pyridoxal is selectively phosphorylated on the 5'-hydroxymethyl group under formation of p-phenetidyl-pyridoxal-5'-phosphate; p-phenetidyl- pyridoxal-5'-phosphate is hydrolysed under formation of an alkali metal salt of pyridoxal-5'-phosphate; the alkali metal ions are removed in order to obtain pyridoxal-5'-phosphate; pyridoxal-5'-phosphate is reacted with a reaction product of a magnesium alcoholate and L-glutamic acid; and the formed magnesium pyridoxal-5'-phosphate glutamate is isolated. Furthermore, the invention relates to intermediate products obtained with this method.

L'invention concerne un procédé de production de glutamate de pyridoxal-5'-phosphate de magnésium, comprenant les étapes consistant: à oxyder une pyridoxine, ou un sel d'addition d'acide de celle-ci, à l'aide d'un oxyde de manganèse (IV), afin d'obtenir un pyridoxal; à faire réagir ce pyridoxal avec une p-phénétidine, cette réaction se faisant avec la formation de p-phénétidyl-pyridoxal de base de Schiff; à phosphoryler ce p-pnénétidyl-pyridoxal de manière sélective sur le groupe 5'-hydroxyméthyle, avec formation de -p-phénétidyl-pyridoxal-5'-phosphate; à hydrolyser ce p-phénétidyl-pyridoxal-5'-phosphate, avec formation d'un sel métallique alcalin de pyridoxal-5'-phosphate; à enlever les ions métalliques alcalins afin d'obtenir un pyridoxal-5'-phosphate; à faire réagir ce pyridoxal-5'-phosphate avec un produit de réaction d'un alcoolat de magnésium et d'un acide L-glutamique, et enfin à isoler le glutamate de pyridoxal-5'-phosphate de magnésium ainsi formé. En outre, l'invention concerne des produits intermédiaires obtenus selon ce procédé.

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