Method for the production of maytansinoids

Details Method for the production of maytansinoids Method for the production of maytansinoids

C - Chemistry, Metallurgy

07

D

260/237.1

C07D 498/18 (2006.01) C07D 498/04 (2006.01)

Patent

CA 1097627

Method for the Production of Maytansinoids ABSTRACT OF THE DISCLOSURE Maytansinoid compounds are produced by contacting in the presence of a carbodiimide the compound maytansinol Image with an acid of the formula: Image (II) wherein R is lower alkyl, to yield the desired maytansinoids having the resultant formula: - 1 - Image (I) wherein R is lower alkyl. The maytansinoids (I) are both antifungal agents and also antitumor agents. The D-form (with respect to asymmetry at the 2'- position) of the maytansinoids (I) represents a new class of compounds having antifungal and antitumor properties. - 2 -

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