Method for the production of oxazoles by condensing aromatic...

C - Chemistry – Metallurgy – 07 – D

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C07D 263/32 (2006.01) A61K 31/41 (2006.01) A61P 3/00 (2006.01)

Patent

CA 2590494

Disclosed is a method for producing oxazoles of formula IV by condensing aromatic aldehydes with a-ketoximes to N-oxides and then reacting the same with activated acid derivatives. The invention relates to a method for producing oxazoles by condensing aldehydes with a-ketoximes to N-oxides in the form of the salts thereof or as free bases and then reacting the same with activated acid derivatives so as to obtain oxazoles in the form of the salts thereof or as free bases.

L'invention concerne un procédé de fabrication d'oxazoles représentés par la formule (IV), par condensation d'aldéhydes aromatiques avec des .alpha.-cétoximes afin de produire des N-oxydes et réaction consécutive avec des dérivés d'acide activés. L'invention concerne également un procédé de fabrication d'oxazoles par condensation d'aldéhydes aromatiques avec des .alpha.-cétoximes afin de produire des N-oxydes sous la forme de leurs sels et bases libres et réaction consécutive avec des dérivés d'acide activés afin de produire des oxazoles sous la forme de leurs sels et bases libres.

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