Method for the production of rdspa .alpha.1

Details Method for the production of rdspa .alpha.1 Method for the production of rdspa .alpha.1

C - Chemistry, Metallurgy

12

N

C12N 9/72 (2006.01) A61K 38/49 (2006.01) C07K 1/16 (2006.01) C12N 9/64 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2245554

rDSPA .alpha. 1 is produced in commercial quantities and a purity adequate for clinical standards. The production methods utilize a series of chromatographic steps: cation exchange chromatography, followed by hydrophobic interaction chromatography, and ending with affinity chromatography.

On produit des quantités commerciales de rDSPA alpha possédant une pureté répondant à des normes cliniques. Le procédé de producti on met en application une série d'étapes chromatographiques, à savoir d'abord une chromatographie d'échanges de cations, suivie par une technique de chromatographie d'interaction hydrophobe et, enfin, une chromatographie d'affinité.

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