C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 1/113 (2006.01) C07K 14/61 (2006.01)
Patent
CA 2344506
The invention relates to a method for the production of recombinant peptides with a low amount of trisulfides which is characterized by the addition of a metal salt during or after the fermentation step and to a method for reduction of the amount of trisulfides in the production of recombinant peptides, characterized by the addition of a metal salt during or after fermentation. The peptide is preferably human growth hormone and the salt preferably a potassium or sodium phosphate.
L'invention concerne un procédé de production de peptides recombinés à faible teneur en trisulfures, caractérisé par l'addition d'un sel métallique pendant ou après l'opération de fermentation. L'invention concerne également un procédé de réduction de la teneur de trisulfures lors de la production de peptides recombinés, caractérisé par l'addition d'un sel métallique pendant ou après la fermentation. Le peptide est, de préférence, une hormone de croissance humaine et le sel, de préférence, un phosphate de potassium ou de sodium.
Castan Andreas
Hemmendorff Barbro
Persson Anders
Ab Pharmacia
Gowling Lafleur Henderson Llp
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