C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
195/120
C12P 19/28 (2006.01) C12P 19/38 (2006.01)
Patent
CA 1297057
-0- METHOD FOR THE PRODUCTION OF RIBAVIRIN USING HIGH RIBOSE DONOR CONCENTRATIONS Abstract of the Disclosure A method for the production of A 1,2,4-triazole nucleoside comprising the step of reacting a ribose donor with a triazole compound in the presence of an enzyms preparation derived from Brevibacterium acetylicum is disclosed. The method is characterized in that the ribose donor is guanosine; the concentration of the donor is above about 100 mM; and the enzyme preparation is added before the reaction mixture gells. The method is capable of high production rates and high concentrations of the final product.
558442
Genencor International Inc.
Gowling Lafleur Henderson Llp
Pochodylo James Michael
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