Method for the production of ribavirin using high ribose...

C - Chemistry – Metallurgy – 12 – P

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C12P 19/28 (2006.01) C12P 19/38 (2006.01)

Patent

CA 1297057

-0- METHOD FOR THE PRODUCTION OF RIBAVIRIN USING HIGH RIBOSE DONOR CONCENTRATIONS Abstract of the Disclosure A method for the production of A 1,2,4-triazole nucleoside comprising the step of reacting a ribose donor with a triazole compound in the presence of an enzyms preparation derived from Brevibacterium acetylicum is disclosed. The method is characterized in that the ribose donor is guanosine; the concentration of the donor is above about 100 mM; and the enzyme preparation is added before the reaction mixture gells. The method is capable of high production rates and high concentrations of the final product.

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