Method for the production of sialylated oligosaccharides

Details Method for the production of sialylated oligosaccharides Method for the production of sialylated oligosaccharides

C - Chemistry, Metallurgy

12

P

C12P 19/26 (2006.01) C12N 9/10 (2006.01) C12Q 1/48 (2006.01)

Patent

CA 2337078

Disclosed are methods for the enzymatic synthesis of .alpha.-sialylated oligosaccharide glycosides. Specifically, in the disclosed methods, .alpha.2,3- sialyltransferase is used to transfer an analogue of sialic acid, employed as its CMP-nucleotide derivative, to the non-reducing sugar terminus of an oligosaccharide having a fucosyl group in the penultimate saccharide unit to the non-reducing sugar terminus. The analogue of sialic acid and the oligosaccharide employed in this method are selected to be compatible with the sialyltransferase employed.

L'invention porte sur des procédés de synthèse enzymatique de glycosides oligosaccharides .alpha. sialylés utilisant spécifiquement de la .alpha.2,3 sialyltransférase pour transférer un analogue de l'acide sialique (employé comme son dérivé de nucléotide de CMP) sur le terminus de sucre non réducteur d'un oligosaccharide présentant un groupe fucosyle dans l'unité saccharide pénultième du terminus de sucre non réducteur. L'analogue de l'acide sialique et l'oligosaccharide utilisés dans ce procédé sont choisis pour être compatibles avec la sialyltransférase.

Affiliated with

Also associated with

Rating

Method for the production of sialylated oligosaccharides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for the production of sialylated oligosaccharides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for the production of sialylated oligosaccharides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2074655