C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) C07K 1/18 (2006.01) C12N 7/02 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2410948
Methods of production and purification for viruses and virus-derived vectors, including those related to alphaviruses, are disclosed. In one aspect, methods of purification that subject alphavirus replicon particle preparations to one or more steps of chromatographic purification, such as using an ion exchange resin, are provided. Also disclosed are methods of characterizing alphavirus replicon particles and utilizing these materials for vaccines and gene-based therapeutics.
L'invention porte sur des procédés de production et de purification de virus et de vecteurs dérivés de virus, y compris ceux relatifs aux alphavirus. En variante, l'invention porte sur des procédés de purification qui soumettent des préparations de particules de réplicon des alphavirus à une ou plusieurs étapes de purification chromatographique en utilisant, par exemple, une résine échangeuse d'ions. L'invention porte également sur des procédés de caractérisation des particules de réplicon des alphavirus et d'utilisation de ces matériaux dans des thérapies à base de vaccins et de gènes.
Belli Barbara
Calderon-Cacia Maria
de La Vega Daniel Jr.
Dubensky Thomas W. Jr.
Greer Catherine
Borden Ladner Gervais Llp
Chiron Corporation
Novartis Vaccines And Diagnostics Inc.
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