C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/02 (2006.01) A61K 39/275 (2006.01) C12N 15/86 (2006.01) C12N 15/863 (2006.01)
Patent
CA 2467099
The present invention relates to a method for the recovery of poxviruses, in particular modified Vaccinia virus Ankara (MVA), from infected cells. According to the present invention the virus-infected cells are subjected to a high-pressure homogenization to obtain a virus containing homogenate. The virus containing homogenate can be subjected to at least one purification step to obtain apoxvirus-enriched fraction. The invention further relates to the virus containing fraction and the virus containing homogenate obtained by the method according to the present invention.
La présente invention porte sur un procédé de récupération des poxvirus, tels que le virus de la vaccine modifié Ankara (MVA), dans des cellules infectées. Selon cette invention, les cellules infectées par le virus sont soumises à une homogénéisation haute pression de façon à obtenir un homogénat contenant le virus. Cet homogénat peut être soumis à au moins une étape de purification de façon à obtenir une fraction enrichie en apoxvirus. L'invention porte également sur une fraction contenant le virus et sur l'homogénat contenant le virus obtenus selon le procédé de l'invention.
Heller Karl
Kramer Jutta
Bavarian Nordic A/s
Smart & Biggar
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