Method for the reduction of heterogeneity of monoclonal...

Details Method for the reduction of heterogeneity of monoclonal... Method for the reduction of heterogeneity of monoclonal...

C - Chemistry, Metallurgy

12

P

195/128.1, 195/1

C12P 21/08 (2006.01) C07K 16/00 (2006.01)

Patent

CA 1332367

Abstract Novel methods for reducing the heterogeneity of secreted monoclonal antibodies are disclosed. The first method comprises incubating the heterogeneous antibodies at low pH for a length of time sufficient to convert the heterogeneous forms of antibodies into substantially homogeneous forms. Another method produces the same result using ascites fluid, while yet another method produces the same result using carboxypeptidase. The homogeneous antibodies can then be purified in high yield.

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