Method for the reductive methylation of primary amines

Details Method for the reductive methylation of primary amines Method for the reductive methylation of primary amines

C - Chemistry, Metallurgy

07

C

260/607.2

C07C 209/68 (2006.01) C07C 209/26 (2006.01) C07C 211/14 (2006.01)

Patent

CA 2005892

ABSTRACT A process for the preparation of permethylated amines, particularly pentamethyldiethylenetriamine, by the reductive methylation of diethylenetriamine in the presence of hydrogen, a nickel-containing catalyst, aqueous formaldehyde and methanol, comprising feeding continuously the formaldehyde to the reaction system in two phases. In the first phase, a sufficient amount of formaldehyde to mono-methylate the primary amine groups present, is fed to the reaction system at a high flow rate, and thereafter the flow rate of the formaldehyde is substantially reduced, for the reductive methylation of the secondary amine groups. By this method the pro- duction of by-products is substantially reduced and preparation times are significantly shorter in compar- ison to processes where the formaldehyde flow rate remains constantly high for the entirety of the reaction.

Affiliated with

Also associated with

Rating

Method for the reductive methylation of primary amines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for the reductive methylation of primary amines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for the reductive methylation of primary amines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1632823